Benzyl 4-ethoxycarbonylmethoxybutyrate → 4-Ethoxycarbonylmethoxybutyric acid

HRID 487490Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 487490
[CH2:1]([O:3][C:4]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC1C=CC=CC=1)=[O:12])=[O:5])[CH3:2]>O1CCCC1.[Pd]>[CH2:1]([O:3][C:4]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:5])[CH3:2]

Komponenten

4

Edukt 1

HCID 18991532Benzyl 4-ethoxycarbonylmethoxybutyrate

Produkt 1

HCID 223185004-Ethoxycarbonylmethoxybutyric acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

45 g (0.16 mol) of benzyl 4-ethoxycarbonylmethoxybutyrate 58 g are dissolved in 450 ml of tetrahydrofuran and the solution is hydrogenated under normal pressure at room temperature by addition of 4.5 g of 5% Pd/C. Upon cessation of hydrogenation, the catalyst is removed by filtration and the filtrate is concentrated by evaporation giving 4-ethoxycarbonylmethoxybutyric acid which is further reacted without purification.

Aufarbeitung

  1. customUpon cessation of hydrogenation, the catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-a7f5352e903e466fa5d39e2b328fab09
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05294734

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