2,4,6-Trimethylpyridine → (4R)-N-(2-Nitrooxyethyl)-2-oxothiazolidine-4-carboxamide

0.44 g of nitronium tetrafluoroborate and a solution of 0.41 g of 2,4,6-collidine in 20 ml of acetonitrile were added at a temperature of from -10° C. to 0° C. to 30 ml of acetonitrile, and the resulting mixture was stirred at the same temperature for 30 minutes. At the end of this time, 0.50 g of (4R)-N-(2-hydroxyethyl)-2-oxothiazolidine-4-carboxamide was added to the mixture, and the mixture was stirred at room temperature for 4 hours. The reaction mixture was then freed from the solvent by distillation under reduced pressure. The residue was mixed with ethyl acetate and insoluble materials were filtered off. The filtrate was concentrated by evaporation under reduced pressure, and the resulting residue was purified by column chromatography through silica gel, using ethyl acetate as the eluent. The pale yellow crystals thus obtained were recrystallized from ethyl acetate, to give 86 mg of the title compound as colorless crystals. The melting point and nuclear magnetic resonance spectrum of the product were identical with those of the compound produced as described in Example 1.

1. stirringthe mixture was stirred at room temperature for 4 hours
2. distillationThe reaction mixture was then freed from the solvent by distillation under reduced pressure
3. additionThe residue was mixed with ethyl acetate and insoluble materials
4. filtrationwere filtered off
5. concentrationThe filtrate was concentrated by evaporation under reduced pressure
6. customthe resulting residue was purified by column chromatography through silica gel
7. customThe pale yellow crystals thus obtained
8. customwere recrystallized from ethyl acetate

ORD-Eintrag

ord-c3ce8dd6e973459bbba07576cf96a52e

Quelldatensatz

uspto-grants-1994_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05298516