Chloroacetone → 1-((4-Bromophenyl)thio)propan-2-one

HRID 487984Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 487984
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[OH-].[Na+].Cl[CH2:12][C:13](=[O:15])[CH3:14]>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:12][C:13](=[O:15])[CH3:14])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6571ChloroacetoneHCID 14798Sodium HydroxideHCID 660494-Bromothiophenol

Produkt 1

HCID 8219021-((4-Bromophenyl)thio)propan-2-oneAusbeute 104,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-bromothiophenol (5.09 g, 26.9 mmol) in NaOH (1.08 g, 26.9 mmol) and water (32 ml) was added chloroacetone (2.17 ml, 27.3 mmol) and the mixture was stirred under nitrogen for 45 min before extracting with ether, washing with water, drying (Na2SO4) and evaporating in vacuo, leaving 6.89 g (100%) of the title compound as a white solid, δ (CDCl3) 2.27 (3H, s), 3.65 (2H, s), 7.20 (2H, d, J=8.5 Hz), 7.41 (2H, d, J=8.5 Hz).

Aufarbeitung

  1. extractionbefore extracting with ether
  2. washwashing with water
  3. dry with materialdrying (Na2SO4)
  4. customevaporating in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c1982fcc1abe4d62a6efe6616df2da46
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05298520

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