2-Bromobenzyl bromide → 1-Bromo-2-(methoxymethyl)benzene

HRID 488018

Reaktionsgleichung

Reaktionsgleichung von HRID 488018
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[CH3:10][O-:11].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:11][CH3:10]

Komponenten

4

Edukt 2

HCID 769652-Bromobenzyl bromideHCID 10942334Sodium Methoxide

Produkt 1

HCID 129271621-Bromo-2-(methoxymethyl)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

685 g (2.74 mol) of o-bromobenzyl bromide was refluxed with 2.74 mol of a 30% strength sodium methylate solution in methanol for 15 hours. After the mixture had cooled to room temperature it was evaporated down, taken up in ethyl acetate, and washed with water. After the organic phase had been dried over sodium sulfate, it was again evaporated down. There was obtained 478.2 g (87%) of the title substance as a colorless liquid.

Aufarbeitung

  1. customwas evaporated down
  2. washwashed with water
  3. dry with materialAfter the organic phase had been dried over sodium sulfate, it
  4. customwas again evaporated down
  5. customThere was obtained 478.2 g (87%) of the title substance as a colorless liquid

Quellen und Nachweise

ORD-Eintrag
ord-c3460ea5355a4863a64497f82519f589
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05298527

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