Methyl 4-nitropyridine-2-carboxylate → Methyl 4-aminopyridine-2-carboxylate

HRID 488454

Reaktionsgleichung

Reaktionsgleichung von HRID 488454
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1

Komponenten

4

Edukt 1

HCID 3352523Methyl 4-nitropyridine-2-carboxylate

Produkt 1

HCID 3759117Methyl 4-aminopyridine-2-carboxylateAusbeute 94,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of methyl 4-nitropyridin-2-ylcarboxylate (0.7 g) (Deady et. al., Aus. J. Chem. 24 (1971)385-390) in methanol (30 ml) was treated with 10% Pd/C (0.3 g) and stirred under hydrogen at atmospheric pressure overnight. The solution was filtered and evaporated to yield the title compound (0.55 g). NMR δ(CDCl3) 3.97(3H,s), 4.34(2H, broad), 6.65(1H,dd), 7.39(1H,d), 8.32(1H,d).

Aufarbeitung

  1. filtrationThe solution was filtered
  2. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-7f1060c725a74a8e9560e611ae4b9716
Quelldatensatz
uspto-grants-2005_12
Patentnummer
US06972297B2

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