2-Chlorobenzoic Acid → 2-{4-[2-(4-Dibutylamino-phenyl)-ethyl]phenylamino}-benzoic acid
Reaktionsgleichung
Cl[C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(N[C:16]1([NH:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=2)=[CH:18][CH2:17]1)CCC.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.[Cu].[Cu]Cl>[CH2:10]([N:31]([CH2:32][CH2:33][CH2:34][CH3:35])[C:16]1[CH:17]=[CH:18][C:19]([CH2:22][CH2:23][C:24]2[CH:25]=[CH:26][C:27]([NH:30][C:2]3[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=3[C:4]([OH:6])=[O:5])=[CH:28][CH:29]=2)=[CH:20][CH:21]=1)[CH2:2][CH2:3][CH3:4]Komponenten
7
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
The title compound was prepared from 2-chlorobenzoic acid (1.46 g, 9.36 mmol), 4-[2-(4,4-dibutylaminophenyl)ethyl]phenylamine (3.31 g, 10.20 mmol), anhydrous potassium carbonate (4.27 g, 30.88 mmol), copper powder (1.25 g, 19.65 mmol), and copper(I) chloride (0.092 g, 0.93 mmol) in dry DMF (30 mL) using the procedure described in Example 1, Step C, Method B. This procedure yielded a 0.39 g (0.87 mmol, 8.6%) of the desired product. mp 115-117° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-e0761f2215a5472dac2c64bded80ab9e
- Quelldatensatz
- uspto-grants-2005_12
- Patentnummer
- US06972287B1
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