methyl (2Z)-2-(acetylamino)-3-(4-amino-3-isopropylphenyl)acrylate → methyl N-acetyl-4-amino-3-isopropylphenylalaninate

HRID 488652Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 488652
[C:1]([NH:4]/[C:5](=[CH:10]\[C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[C:13]([CH:18]([CH3:20])[CH3:19])[CH:12]=1)/[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([NH:4][C@H:5]([C:6]([O:8][CH3:9])=[O:7])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[C:13]([CH:18]([CH3:20])[CH3:19])[CH:12]=1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 86585325methyl (2Z)-2-(acetylamino)-3-(4-amino-3-isopropylphenyl)acrylateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 69803103methyl N-acetyl-4-amino-3-isopropylphenylalaninate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

methyl (2Z)-2-(acetylamino)-3-(4-amino-3-isopropylphenyl)acrylate (752 mg, 2.72 mmole) and 10% Pd/C (143 mg) stirred in ethanol (20 mL) under 1 atmosphere of hydrogen for 16 hours. The mixture was filtered through Celite and the filtrate was concentrated under reduced pressure to provide the titled compound.

Aufarbeitung

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-40f018eea4dd47d8859cea3850569147
Quelldatensatz
uspto-grants-2005_12
Patentnummer
US06972340B2

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