Bromine → 2-Bromo-1,3-diphenyl-1-propanone

HRID 488770

Reaktionsgleichung

Reaktionsgleichung von HRID 488770
[C:1]1([C:7](=[O:16])[CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:17]Br>O1CCOCC1>[Br:17][CH:8]([CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:16]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 64802Dihydrochalcone2×

Produkt 1

HCID 30396872-Bromo-1,3-diphenyl-1-propanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a solution of 1,3-diphenylpropan-1-one (compound 2) (7.0 mmol) in 25 ml of anhydrous dioxane, a solution of bromine (7.0 mmol) in 10 ml of dioxane was slowly added dropwise over 30 min. The reaction mixture was left to stir at room temperature for 24 hrs to form 2-bromo-1,3-diphenylpropan-1-one (compound 3). Solvent was removed in vacuo. The 2-bromo-1,3-diphenylpropan-1-one product formed was determined by 1H NMR to be sufficiently pure to be used in the next step.

Aufarbeitung

  1. waitThe reaction mixture was left

Quellen und Nachweise

ORD-Eintrag
ord-7893031004964d65825ebce55d7a7866
Quelldatensatz
uspto-grants-2005_12
Patentnummer
US06974830B2

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