Potassium Carbonate → 3-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazole

HRID 4896

Reaktionsgleichung

Reaktionsgleichung von HRID 4896
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([C:13]1[N:17]=[C:16]([CH2:18]Cl)[O:15][N:14]=1)[CH:11]=[CH2:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:10]([C:13]1[N:17]=[C:16]([CH2:18][O:9][C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[Cl:1])[O:15][N:14]=1)[CH:11]=[CH2:12]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 748142-Chloro-4-fluorophenolHCID 197971305-(Chloromethyl)-3-(prop-2-en-1-yl)-1,2,4-oxadiazole

Produkt 1

HCID 197971293-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazoleAusbeute 80,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

0.71 g of 2-chloro-4-fluorophenol, 0.77 g of 3-allyl-5-chloromethyl-1,2,4-oxadiazole and 0.83 of potassium carbonate were added to 20 ml of acetone. After completion of the reaction, the resulting precipitates were filtered out from the mixture and then acetone was removed by distillation, and the residue was purified by column chromatography (benzene:hexane=1:1) to obtain 1.05 g of the desired product(yield: 80.8%).

Aufarbeitung

  1. customAfter completion of the reaction
  2. customthe resulting precipitates
  3. filtrationwere filtered out from the mixture
  4. customacetone was removed by distillation
  5. customthe residue was purified by column chromatography (benzene:hexane=1:1)

Quellen und Nachweise

ORD-Eintrag
ord-78085214e0d5496ab614bdad6a715709
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05242890

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