3-Methyl-5-nitroisoquinoline → 3-Methylisoquinolin-5-amine

HRID 490287

Reaktionsgleichung

Reaktionsgleichung von HRID 490287
[CH3:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([N+:12]([O-])=O)[CH:8]=[CH:7][CH:6]=2>[Pd].CO>[CH3:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([NH2:12])[CH:8]=[CH:7][CH:6]=2

Komponenten

4

Edukt 1

HCID 2749733-Methyl-5-nitroisoquinoline

Produkt 1

HCID 122120553-Methylisoquinolin-5-amineAusbeute 76,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of (D1) (1 g, 5.3 mM) and 10% palladium on charcoal (0.15 g) in methanol (40 ml) was hydrogenated at atmospheric pressure for 1 h. The catalyst was filtered off and the filtrate concentrated under reduced pressure to afford the product as a grey solid (0.64 g).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-75455a89fbf143aba118e50ac228915c
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528150B2

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