1,3-Dimethyl-5-nitroisoquinoline → 1,3-Dimethylisoquinolin-5-amine

HRID 490294Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490294
[CH3:1][C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-])=O)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([CH3:15])[N:3]=1>[Pd].CO>[NH2:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[CH:5]=[C:4]([CH3:15])[N:3]=[C:2]2[CH3:1]

Komponenten

4

Edukt 1

HCID 574567801,3-Dimethyl-5-nitroisoquinoline

Produkt 1

HCID 223376241,3-Dimethylisoquinolin-5-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of D3 (2.01 g, 9.94 mM) and 10% palladium on charcoal (1 g) in methanol was hydrogenated at atmospheric pressure for 1 h. The catalyst was filtered off and the filtrate concentrated under reduced pressure to afford the product as a cream coloured solid.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate concentrated under reduced pressure
  3. customto afford the product as a cream

Quellen und Nachweise

ORD-Eintrag
ord-1e67d1e7b4f7433aba057a86e660f1cd
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528151B2

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