1-Benzyl-5-nitro-1,2-dihydro-3h-indazol-3-one → HCID 68730847, Verbindung

HRID 490552Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490552
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([N+:17]([O-])=O)=[CH:14][CH:15]=2)[C:10](=[O:20])[NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pd]>[NH2:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[N:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[NH:9][C:10]2=[O:20]

Komponenten

4

Edukt 1

HCID 3849951-Benzyl-5-nitro-1,2-dihydro-3h-indazol-3-one

Produkt 1

HCID 68730847HCID 68730847, VerbindungAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1-benzyl-5-nitro-1,2-dihydro-indazol-3-one (0.44 g) in MeOH (50 mL) was added Pd/C(10%) catalyst (0.1 g) and the reaction mixture was stirred for four hours at ambient temperature under a hydrogen atmosphere using a balloon. After this time the reaction mixture was filtered through Celite® which was washed with more EtOAc. The combined organic solution was evaporated in vacuo for afford the desired 5-amino-1-benzyl-1,2-dihydro-indazol-3-one (0.39 g) which was taken into the next reaction without further purification. MS (ESI+): 240.1 ([M+H]+).

Aufarbeitung

  1. filtrationAfter this time the reaction mixture was filtered through Celite® which
  2. washwas washed with more EtOAc
  3. customThe combined organic solution was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a94f0d8804e84c1ca686bc7032f4d9e9
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528158B2

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