Lithium Hydroxide → 1-Benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid

HRID 490581Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490581
C[O:2][C:3]([CH:5]1[CH2:9][CH:8]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][N:6]1[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:4].[Li+].[OH-]>C1COCC1.O>[CH2:18]([N:6]1[CH2:7][CH:8]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:9][CH:5]1[C:3]([OH:4])=[O:2])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 675488361-Benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid methyl ester

Produkt 1

HCID 675466961-Benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21881883Oxolane--water (1/1)Lösungsmittel

Versuchsvorschrift

1-Benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid methyl ester and LiOH are dissolved in THF/H2O, and then stirred overnight. After removal of solvent, the residue is neutralized to PH=6-7, and then extracted by EA. The organic layer is washed with water and brine, dried, and concentrated to afford 1-benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid (4).

Aufarbeitung

  1. customAfter removal of solvent
  2. extractionextracted by EA
  3. washThe organic layer is washed with water and brine
  4. customdried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6fbd808a1da84d5aaba72313f0278eb6
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528136B2

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