1-Methyl-2-nitro-3-(trifluoromethyl)benzene → 2-Amino-3-methylbenzotrifluoride

HRID 491146Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 491146
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[C:3]=1[N+:12]([O-])=O.[H][H]>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:9])([F:10])[F:11])[C:3]=1[NH2:12]

Komponenten

5

Edukt 2

HCID 134554311-Methyl-2-nitro-3-(trifluoromethyl)benzeneHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 133182332-Amino-3-methylbenzotrifluoride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 50 g (0.24 mol) 1-methyl-2-nitro-3-trifluoromethyl-benzene and 4.4 g 10% Pd/C in 300 mL MeOH was hydrogenated at RT and 3000 hPa hydrogen pressure until the theoretical amount of hydrogen had been taken up. The catalyst was filtered off, washed with MeOH and the filtrate was evaporated down. The crude product was further reacted without purification.

Aufarbeitung

  1. customwas hydrogenated at RT
  2. filtrationThe catalyst was filtered off
  3. washwashed with MeOH
  4. customthe filtrate was evaporated down
  5. customThe crude product was further reacted without purification

Quellen und Nachweise

ORD-Eintrag
ord-2e76dbfa524e4d0db4d230b5fb152532
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528129B2

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