Bromine → 4-Bromo-2-methyl-6-(trifluoromethyl)aniline

HRID 491147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 491147
[Br:1]Br.[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:5]=1[NH2:14].C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[Br:1][C:8]1[CH:7]=[C:6]([C:10]([F:11])([F:12])[F:13])[C:5]([NH2:14])=[C:4]([CH3:3])[CH:9]=1

Komponenten

5

Edukt 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 133182332-Amino-3-methylbenzotrifluoride

Produkt 1

HCID 674070344-Bromo-2-methyl-6-(trifluoromethyl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

Under a nitrogen atmosphere a solution of 11.0 mL (214 mmol) bromine in 100 mL chloroform was added dropwise to a solution of 35.8 g (204 mmol) 2-methyl-6-trifluoromethyl-phenylamine in 350 mL chloroform and after the end of the addition the reaction mixture was stirred for 3 h at RT. Saturated NaHCO3 solution was added with stirring, the mixture was stirred for a further 20 min at RT, the organic phase was separated off and dried over Na2SO4. After the desiccant and solvent had been eliminated the product was obtained as an oil, which was further reacted without purification.

Aufarbeitung

  1. additionafter the end of the addition the reaction mixture
  2. stirringwith stirring
  3. stirringthe mixture was stirred for a further 20 min at RT
  4. customthe organic phase was separated off
  5. dry with materialdried over Na2SO4
  6. customwas obtained as an oil, which
  7. customwas further reacted without purification

Quellen und Nachweise

ORD-Eintrag
ord-b14d31bb223343a5b15d6fe37075c20b
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528129B2

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