Chloroacetaldehyde → 6-Bromo-N-(2-thiazolyl)pyridin-2-amine

HRID 49140

Reaktionsgleichung

Reaktionsgleichung von HRID 49140
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][C:9]([NH2:11])=[S:10])[N:3]=1.Cl[CH2:13][CH:14]=O>C(O)C.O>[Br:1][C:2]1[N:3]=[C:4]([NH:8][C:9]2[S:10][CH:13]=[CH:14][N:11]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 33ChloroacetaldehydeHCID 22170428(6-Bromo-pyridin-2-YL)thiourea

Produkt 1

HCID 221704016-Bromo-N-(2-thiazolyl)pyridin-2-amineAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A suspension of 2-bromo-6-thioureidopyridine (3 g, 12.92 mmol) and chloroacetaldehyde (3.28 mL, 25.85 mmol) in ethanol (27 mL) and water (7 mL) was heated at reflux for 4.75 h. The solution was concentrated in vacuo and the residue was diluted with 1 N aqueous NaOH solution at 0° C., stirred for 10 min, and the pH was then adjusted to 8.5 by addition of 6 N aqueous HCl solution. The precipitate was collected by filtration, washed several times with water and dried in vacuo over P2O5 to obtain the titled compound (3.17 g, 96%) as a light yellow solid.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 4.75 h
  3. concentrationThe solution was concentrated in vacuo
  4. additionthe residue was diluted with 1 N aqueous NaOH solution at 0° C.
  5. additionthe pH was then adjusted to 8.5 by addition of 6 N aqueous HCl solution
  6. filtrationThe precipitate was collected by filtration
  7. washwashed several times with water
  8. dry with materialdried in vacuo over P2O5

Quellen und Nachweise

ORD-Eintrag
ord-6008bb2fbb9e4cdab9922f9daf64bc80
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06706717B2

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