3-(4-amino-3-nitro-phenoxy)-N-methyl-benzamide → 3-(3,4-Diamino-phenoxy)-N-methyl-benzamide

HRID 491632

Reaktionsgleichung

Reaktionsgleichung von HRID 491632
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10]([NH:12][CH3:13])=[O:11])=[CH:4][C:3]=1[N+:19]([O-])=O>CO.[Pd]>[NH2:19][C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][C:2]=1[NH2:1])[O:6][C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([NH:12][CH3:13])=[O:11]

Komponenten

4

Edukt 1

HCID 690175323-(4-amino-3-nitro-phenoxy)-N-methyl-benzamide

Produkt 1

HCID 690171513-(3,4-Diamino-phenoxy)-N-methyl-benzamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

3-(4-Amino-3-nitro-phenoxy)-N-methyl-benzamide (Step B, 0.5 g, 1.7 mmol, 1.0 eq.) was dissolved in MeOH (10 mL) and the atmosphere was replaced by argon. A catalytic amount of 10% Pd/C was added and the argon was replaced by a H2 atmosphere. The mixture was stirred for 16 h at RT at atmospheric pressure. The Pd/C was filtered off and the obtained 3-(3,4-diamino-phenoxy)-N-methyl-benzamide was used crude in the next step.

Aufarbeitung

  1. filtrationThe Pd/C was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-41fde00c3b9b42b1b5c8233aa1c204c5
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07531553B2

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