Hydrochloric Acid → 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid cyclohexylamide

HRID 491894Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 491894
[CH2:1]([N:8]1[CH:12]=[N:11][C:10]([C:13]([OH:15])=O)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.C(N(CC)C(C)C)(C)C.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.Cl>CN(C=O)C>[CH:16]1([NH:22][C:13]([C:10]2[N:11]=[CH:12][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[N:9]=2)=[O:15])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Komponenten

7

Edukt 5

HCID 313Hydrochloric AcidHCID 7965CyclohexylamineHCID 81531DiisopropylethylamineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 157079191-Benzyl-1H-1,2,4-triazole-3-carboxylic acid

Produkt 1

HCID 670235851-benzyl-1H-[1,2,4]triazole-3-carboxylic acid cyclohexylamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a stirred solution of 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid (1.54 g, 7.6 mmol), cyclohexylamine (0.87 mL, 7.6 mmol) and N,N-diisopropylethylamine (2.65 mL, 15.1 mmol) in DMF (30 mL) was added HBTU (3.45 g, 9.1 mmol). The solution was then stirred at room temperature overnight. Aqueous hydrochloric acid was added and the solution was filtered to yield 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid cyclohexylamide as a white solid.

Aufarbeitung

  1. filtrationthe solution was filtered

Quellen und Nachweise

ORD-Eintrag
ord-aa2e6891a99c492dafa40db9546ccacb
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07531545B2

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