Ammonium Acetate → 1-Amino-5-(2,5-difluorophenyl)cyclohexan-3-one

HRID 49205

Reaktionsgleichung

Reaktionsgleichung von HRID 49205
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][C:13](=O)[CH2:12][C:11](=[O:16])[CH2:10]1.C([O-])(=O)C.[NH4+:21]>C(O)C>[NH2:21][CH:13]1[CH2:14][CH:9]([C:3]2[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=2[F:1])[CH2:10][C:11](=[O:16])[CH2:12]1

Komponenten

4

Edukt 2

HCID 517165Ammonium AcetateHCID 178239175-(2,5-Difluorophenyl)cyclohexane-1,3-dione

Produkt 1

HCID 178239181-Amino-5-(2,5-difluorophenyl)cyclohexan-3-oneAusbeute 92,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 5-(2,5-difluorophenyl)cyclohexane-1,3-dione (4.0 g) and ammonium acetate (4.1 g) in ethanol (60 ml) was heated under reflux for 12 hours. The reaction mixture was concentrated under reduced pressure, and the residue was washed with water and dried to obtain 1-amino-5-(2,5-difluorophenyl)cyclohexan-3-one (3.7 g).

Aufarbeitung

  1. temperatureunder reflux for 12 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. washthe residue was washed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-127ad5525e15414fa8391ce0006812bd
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06706732B1

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