Triethylamine → N'-[(2'-nitro-1,1'-biphenyl-4-yl)methyl]-N'-pentyl-N-(2,4,6-trifluorophenyl)urea

HRID 492290

Reaktionsgleichung

Reaktionsgleichung von HRID 492290
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([F:12])[C:3]=1C(O)=O.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:20])C=CC=CC=1.[N+:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[C:39]1[CH:44]=[CH:43][C:42]([CH2:45][NH:46][CH2:47][CH2:48][CH2:49][CH2:50][CH3:51])=[CH:41][CH:40]=1)([O-:32])=[O:31].C([N:54]([CH2:57]C)CC)C>>[N+:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[C:39]1[CH:44]=[CH:43][C:42]([CH2:45][N:46]([CH2:47][CH2:48][CH2:49][CH2:50][CH3:51])[C:57](=[O:20])[NH:54][C:3]2[C:7]([F:12])=[CH:8][C:9]([F:11])=[CH:10][C:2]=2[F:1])=[CH:41][CH:40]=1)([O-:32])=[O:31]

Komponenten

5

Edukt 4

HCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 5203732,4,6-Trifluorobenzoic acidHCID 17860716HCID 17860716, Verbindung

Produkt 1

HCID 68850802N'-[(2'-nitro-1,1'-biphenyl-4-yl)methyl]-N'-pentyl-N-(2,4,6-trifluorophenyl)ureaAusbeute 95 %

Versuchsvorschrift

Using 2,4,6-trifluorobenzoic acid (0.43 g), diphenylphosphoryl azide (0.68 g), triethylamine (0.25 g) and N-[(2′-nitro-1,1′-biphenyl-4-yl)methyl]-N-pentylamine (0.40 g), N′-[(2′-nitro-1,1′-biphenyl-4-yl)methyl]-N′-pentyl-N-(2,4,6-trifluorophenyl)urea (0.60 g) was obtained by a similar procedure as in Example 4. Yield: 95%.

Quellen und Nachweise

ORD-Eintrag
ord-ad60fc8c99314aac82cf2db2c0b61c60
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07531576B2

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