Erythrose, 4-phosphate → D-erythritol 4-phosphate

HRID 493052

Reaktionsgleichung

Reaktionsgleichung von HRID 493052
[Na].[P:2]([O:6][CH2:7][C@@H:8]([OH:13])[C@@H:9]([OH:12])[CH:10]=[O:11])([OH:5])([OH:4])=[O:3].[BH4-].[Na+]>CO>[P:2]([O:6][CH2:7][C@@H:8]([OH:13])[C@@H:9]([OH:12])[CH2:10][OH:11])([OH:4])([OH:5])=[O:3]

Komponenten

5

Edukt 3

HCID 122357Erythrose, 4-phosphateHCID 4311764Sodium borohydrideHCID 5360545Sodium

Produkt 1

HCID 192838D-erythritol 4-phosphate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The sodium salt of D-erythrose 4-phosphate (14.6 mg, 65.7 pmol) is dissolved in methanol (600 μl, 40% (v/v)). Sodium borohydride is added. The reaction is monitored by detection of the aldehyde according to the method of Stahl (Bollinger, H. R., Brenner, M., Gänshirt, H., Mangold, H. K., Seiler, H., Stahl, E. ad Waldi, D. (1964) IN: Dünnschicht-Chromatographie; Ein Laboratoriumshandbuch (ed. Stahl, E.) Springer Verlag, Berlin, Göttingen; Heidelberg). After consumption of the aldehyde the pH of the solution is adjusted with acetic acid to 4-5. The reaction mixture is lyophillized yielding D-erythritol 4-phosphate as a dry compound.

Aufarbeitung

  1. customAfter consumption of the aldehyde the pH of the solution

Quellen und Nachweise

ORD-Eintrag
ord-e425671040d64d4bbd0b13029651ea37
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07534742B2

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