Sodium borohydride → 2-(4-fluorobenzyl)-4-(hydroxymethyl)-10-methoxy-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

HRID 494125Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 494125
[F:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[C:12](=[O:13])[C:11]3[C:14]([O:23][CH3:24])=[C:15]4[C:20](=[O:21])[N:19]([CH3:22])[CH2:18][CH2:17][N:16]4[C:10]=3[C:9]([C:25](OC)=[O:26])=[N:8]2)=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[F:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[C:12](=[O:13])[C:11]3[C:14]([O:23][CH3:24])=[C:15]4[C:20](=[O:21])[N:19]([CH3:22])[CH2:18][CH2:17][N:16]4[C:10]=3[C:9]([CH2:25][OH:26])=[N:8]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 68865248Methyl 2-(4-fluorobenzyl)-10-methoxy-8-methyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxylate

Produkt 1

HCID 688646802-(4-fluorobenzyl)-4-(hydroxymethyl)-10-methoxy-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of methyl 2-(4-fluorobenzyl)-10-methoxy-8-methyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-4-carboxylate (0.10 g, 0.24 mmol) in methanol (4 mL) was treated with sodium borohydride (9 mg, 0.24 mmol). After stirring at room temperature for 30 minutes, the reaction mixture was concentrated under vacuum to half the volume. The white solid precipitated was filtered and air dried to provide the title alcohol.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated under vacuum to half the volume
  2. customThe white solid precipitated
  3. filtrationwas filtered
  4. customair dried

Quellen und Nachweise

ORD-Eintrag
ord-084a15db01844241b3cd0c7424b958c9
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07538112B2

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