Hydrochloric Acid → Ethyl 2-(piperidin-4-yl)acetate

HRID 4949

Reaktionsgleichung

Reaktionsgleichung von HRID 4949
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:3][CH:2]=1.Cl>C(O)C.[H][H].[Pt]=O>[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3][CH2:2]1

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 736321Ethyl pyridine-4-acetate

Produkt 1

HCID 2760465Ethyl 2-(piperidin-4-yl)acetateAusbeute 162,3 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittelHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

16.5 g (0.1 mol) Ethyl 4-pyridylacetate, 8.4 mL (0.1 mol) 12N hydrochloric acid and 2.5 g platinum oxide were dissolved in absolute ethanol and hydrogenated at 40 psi hydrogen on a Parr shaker. After 1 hour, the contents of the vessel were filtered and concentrated in vacuo yielding 27.79 g of ethyl 4-piperidinylacetate.

Aufarbeitung

  1. filtrationthe contents of the vessel were filtered
  2. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4bf57d14da074ba286dc99dcf47db4ab
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05242924

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