Methanol → HCID 57682769, Verbindung

HRID 494999Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 494999
CO.O1CCCC1.C([O:15][C:16]1[C:21]([C:22]([NH:24][CH3:25])=[O:23])=[CH:20][CH:19]=[C:18]([O:26][CH3:27])[C:17]=1[CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][CH:33]([N:36]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([C:45]([NH2:47])=[O:46])[CH:43]=3)[CH:38]=[CH:37]2)[CH2:32][CH2:31]1)C1C=CC=CC=1>[Pd]>[OH:15][C:16]1[C:21]([C:22]([NH:24][CH3:25])=[O:23])=[CH:20][CH:19]=[C:18]([O:26][CH3:27])[C:17]=1[CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][CH:33]([N:36]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([C:45]([NH2:47])=[O:46])[CH:43]=3)[CH:38]=[CH:37]2)[CH2:32][CH2:31]1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 8028TetrahydrofuranHCID 57682824HCID 57682824, Verbindung

Produkt 1

HCID 57682769HCID 57682769, VerbindungAusbeute 100,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

15 ml of methanol and 10 ml of tetrahydrofuran were added to and dissolved in 486 mg of 1-(1-(2-(2-(benzyloxy)-6-methoxy-3-((methylamino)carbonyl)phenyl)ethyl)piperidin-4-yl)-1H-indole-6-carboxamide. Thereafter, 74 mg of 10% Pd—C (containing water) was added thereto, and the obtained mixture was then stirred at room temperature under hydrogen atmosphere overnight. Thereafter, Pd—C was removed by filtration, and the solvent was removed under a reduced pressure, so as to obtain 408 mg of the subject compound.

Aufarbeitung

  1. customThereafter, Pd—C was removed by filtration
  2. customthe solvent was removed under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-91cafb84c28b4cf8b1577b4afd28299c
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07538123B2

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