Acetone → DN9H25S82Z

HRID 495009Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 495009
[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:35])([CH3:34])[O:10]2)=[CH:5][CH:4]=1.[C:37]([OH:44])(=[O:43])/[CH:38]=[CH:39]/[C:40]([OH:42])=[O:41].CC(C)=O>O>[C:37]([OH:44])(=[O:43])/[CH:38]=[CH:39]/[C:40]([OH:42])=[O:41].[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:34])([CH3:35])[O:10]2)=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 180AcetoneHCID 444972Fumaric AcidHCID 11677552E-2110 free base

Produkt 1

HCID 16038980DN9H25S82ZAusbeute 88,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1-{1-[2-(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (1.00 g) and fumaric acid (0.249 g) were dissolved in a mixed solvent consisting of acetone (5 ml) and water (15 ml) at 60° C. Thereafter, the obtained mixture was left at room temperature for 1 hour. The deposited solid was collected by filtration, and the obtained product was then washed with a mixed solvent consisting of acetone (2.5 ml) and water (7.5 ml), so as to obtain the subject compound (1.09 g).

Aufarbeitung

  1. filtrationThe deposited solid was collected by filtration
  2. washthe obtained product was then washed with a mixed solvent

Quellen und Nachweise

ORD-Eintrag
ord-1b0e6c68c95d48d08c2ce61cc609d9cf
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07538123B2

Notizen zur Reaktion

Wird geladen…