Sulfuric Acid → 1-Isoquinolinyloxyacetaldehyde

A mixture of 1-isoquinolinyloxyacetaldehyde dimethyl acetal (0.93 g, 4 mmol), dioxane (10 mL), water (15 mL) and conc. sulfuric acid (2 mmol) was heated at 85° C. for 2 h, then was quenched with saturated aqueous sodium hydrogen carbonate (100 mL). The resulting mixture was extracted with dichloromethane (2×100 mL) and the combined organic extracts were washed with saturated aqueous sodium hydrogen carbonate (50 mL), dried over sodium sulfate and evaporated in vacuo to give the title compound (0.43 g, 57%).

1. customwas quenched with saturated aqueous sodium hydrogen carbonate (100 mL)
2. extractionThe resulting mixture was extracted with dichloromethane (2×100 mL)
3. washthe combined organic extracts were washed with saturated aqueous sodium hydrogen carbonate (50 mL)
4. dry with materialdried over sodium sulfate
5. customevaporated in vacuo

ORD-Eintrag

ord-c65813df7712480da7f56b4b9f71f2eb

Quelldatensatz

uspto-grants-2005_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06939871B2