8-Bromo-6-fluoro-5-methoxy-2-methylquinoline → HCID 22326644, Verbindung

HRID 495439Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 495439
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5](Br)[CH:6]=[C:7]([F:14])[C:8]=2[O:12][CH3:13])[N:3]=1>C(O)C.[Pd]>[F:14][C:7]1[C:8]([O:12][CH3:13])=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([CH3:1])[CH:11]=[CH:10]2

Komponenten

4

Edukt 1

HCID 223267328-Bromo-6-fluoro-5-methoxy-2-methylquinoline

Produkt 1

HCID 22326644HCID 22326644, VerbindungAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-methyl-5-methoxy-6-fluoro-8-bromoquinoline (2.95 g, 10.9 mmol) in ethanol (100 ml) was charged with 10% palladium on charcoal (250 g) and stirred at room temperature and pressure under an atmosphere of hydrogen for 2 h. The mixture was then filtered through a pad of kieselguhr and the filtrate evaporated in vacuo to give the title compound as a brown solid (2.09 g, 100%).

Aufarbeitung

  1. filtrationThe mixture was then filtered through a pad of kieselguhr
  2. customthe filtrate evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a3e83279e57544f3ad0ed44970883c86
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06939871B2

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