HCID 22180109, Verbindung → 5-Amino-2,3-difluoro-4-hydroxy-benzoic acid methyl ester

HRID 495442Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 495442
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([OH:13])=[C:6]([F:14])[C:5]=1[F:15]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([OH:13])=[C:6]([F:14])[C:5]=1[F:15]

Komponenten

4

Edukt 1

HCID 22180109HCID 22180109, Verbindung

Produkt 1

HCID 450896375-Amino-2,3-difluoro-4-hydroxy-benzoic acid methyl esterAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2,3-difluoro-4-hydroxy-5-nitro-benzoic acid methyl ester (2.2 g, 9.4 mmol) in methanol (100 mL) was stirred under atmospheric hydrogen at ambient temperature in the presence of 10% palladium on charcoal (0.8 g) for 3 hours. The mixture was filtered and the filtrate was evaporated in vacuo to give the title compound (1.9 g, 100%) as a colourless solid.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6eb63f00c36748eba755fabaeffac730
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06939871B2

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