Ethyl 2-chlorophenyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate → Ethyl 2-chlorophenyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate

HRID 495613

Reaktionsgleichung

Reaktionsgleichung von HRID 495613
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([C:14]1[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][C:17]([N+:24]([O-])=O)=[CH:16][C:15]=1[N+:27]([O-])=O)[C:9](=[O:13])[O:10][CH2:11][CH3:12]>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([C:14]1[C:19]([C:20]([F:21])([F:23])[F:22])=[CH:18][C:17]([NH2:24])=[CH:16][C:15]=1[NH2:27])[C:9](=[O:13])[O:10][CH2:11][CH3:12]

Komponenten

4

Edukt 1

HCID 20827737Ethyl 2-chlorophenyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate

Produkt 1

HCID 20827736Ethyl 2-chlorophenyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamateAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Ethyl 2-chlorophenyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate (0.645 g) was dissolved in ethyl acetate (100 ml), and to the solution was added 10% Pd—C (0.58 g). The reaction mixture was stirred under hydrogen atmosphere for 11 hours. The catalyst was filtered, and washed with ethyl acetate. The filtrate and washing were combined and concentrated in vacuo to give the title compound (0.543 g, 98%).

Aufarbeitung

  1. filtrationThe catalyst was filtered
  2. washwashed with ethyl acetate
  3. washThe filtrate and washing
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-55614f05576d45bc80a182b2496dd400
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06939887B2

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