Hydrochloric Acid → HCID 178498606, Verbindung

HRID 495973Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 495973
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:20])=[C:7]([C:16]([O:18][CH3:19])=[O:17])[C:8]([C:12]([O:14]C)=[O:13])=[N:9]2)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>O>[C:16]([C:7]1[C:8]([C:12]([OH:14])=[O:13])=[N:9][C:10]2[C:5]([C:6]=1[OH:20])=[CH:4][CH:3]=[C:2]([Cl:1])[CH:11]=2)([O:18][CH3:19])=[O:17]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178418477HCID 178418477, Verbindung

Produkt 1

HCID 178498606HCID 178498606, VerbindungAusbeute 94,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a stirred suspension of dimethyl 7-chloro-4-hydroxyquinoline-2,3-dicarboxylate (1.0 g, 3.38 mmol) in water (20 mL) was added an aqueous solution of sodium hydroxide (0.27 g, 6.75 mmol). Upon addition, the suspension dissolved. The reaction mixture was warmed to 60° C. for 1 hour. After this time the reaction was cooled to room temperature and acidified with concentrated hydrochloric acid. The product was then extracted into diethyl ether and ethyl acetate. The organic extracts were dried over MgSO4, filtered and concentrated in vacuo to provide the title compound as a solid (900 mg). This material was purified by recrystalization employing an ethyl acetate/hexane co-solvent system to provide the title compound (571 mg, 60%) as a white solid mp 296° C. (dec); MS (CI)=238 (M+H). Analysis for C12H8NO5Cl.0.45 CH3CO2CH2CH3.0.10H2O: Calc'd: C, 51.30; H, 3.68; N 4.34, Found: C, 51.28; H, 3.62; N 3.97 1H NMR 8.22 (d, J=8.7 Hz, 1H), 7.92 (d, J=1.8 Hz, 1H), 7.28 (dd, J=8.7, 1.8 Hz, 1H), 3.90 (s, 3H).

Aufarbeitung

  1. additionUpon addition
  2. dissolutionthe suspension dissolved
  3. temperatureAfter this time the reaction was cooled to room temperature
  4. extractionThe product was then extracted into diethyl ether and ethyl acetate
  5. dry with materialThe organic extracts were dried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-621214d00d384193a719435b42c4b822
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06943165B2

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