Diethyl Ether → Ethyl 2-(oxan-2-yloxy)cyclopropane-1-carboxylate

Reaktionsgleichung

[CH:1]([O:3][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][O:5]1)=[CH2:2].[N+](=C[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[N-].[CH3:18]COCC>C([O-])(=O)C.[Rh+3].C([O-])(=O)C.C([O-])(=O)C>[O:5]1[CH2:6][CH2:7][CH2:8][CH2:9][CH:4]1[O:3][CH:1]1[CH2:18][CH:2]1[C:13]([O:15][CH2:16][CH3:17])=[O:14]

Komponenten

Versuchsvorschrift

To a solution of 0.75 mol of the compound obtained in Step 1 in 200 ml of ether there are added 1.5 g of rhodium acetate and then, over 6 hours, a solution of 93 g of ethyl diazoacetate in 50 ml of ether. After stirring at ambient temperature for 16 hours, the reaction mixture is filtered and is then distilled at 50-90° C. and 0.5 torr. The residue obtained is redistilled at 80-84° C. and 0.2 torr, allowing the expected product to be isolated.