Ethyl diazoacetate → Ethyl 2-(benzyloxymethyl)cyclopropanecarboxylate

HRID 496051

Reaktionsgleichung

Reaktionsgleichung von HRID 496051
[N+](=[CH:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])=[N-].[CH2:9]([O:16][CH2:17][CH:18]=[CH2:19])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CCOCC>[CH2:9]([O:16][CH2:17][CH:18]1[CH2:19][CH:3]1[C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 12192Ethyl diazoacetate2×HCID 84542Allyl benzyl ether

Produkt 1

HCID 22325150Ethyl 2-(benzyloxymethyl)cyclopropanecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

31.2 g of ethyl diazoacetate are added to a solution of 0.3 mol of allyl benzyl ether in 150 ml of ether with the aid of a push-syringe. After stirring for 16 hours, 31.2 g of ethyl diazoacetate are added again. After 24 hours the mixture is filtered. The organic phase is washed with saturated NaHCO3 solution and then treated in customary manner. Chromatography over silica gel (dichloromethane) allows the expected product to be obtained.

Aufarbeitung

  1. filtrationAfter 24 hours the mixture is filtered
  2. washThe organic phase is washed with saturated NaHCO3 solution
  3. additiontreated in customary manner
  4. customto be obtained

Quellen und Nachweise

ORD-Eintrag
ord-c809cba580fc45cd9cee4bfaa41681aa
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06943184B2

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