Tetrahydrofuran → (1-(Pyrrolidin-1-yl)cyclopropyl)methanol

HRID 496069Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 496069
[N:1]1([C:6]2([C:9](OCC)=[O:10])[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.O1CCCC1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O>[N:1]1([C:6]2([CH2:9][OH:10])[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

6

Edukt 4

HCID 8028Tetrahydrofuran2×HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 22325082HCID 22325082, Verbindung

Produkt 1

HCID 22325087(1-(Pyrrolidin-1-yl)cyclopropyl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

20.5 g of the product obtained in Step 3 and 100 ml of tetrahydrofuran are poured, over 5 minutes, into a suspension containing 8.57 g of lithium aluminium hydride and 400 ml of tetrahydrofuran. The mixture is heated at reflux for 2 hours, cooled to 5° C. and hydrolysed by successive additions of 9 ml of water, 9 ml of 4N sodium hydroxide solution and then 27 ml of water. The aluminium compound is filtered off and rinsed with tetrahydroflran. The combined filtrates are concentrated to dryness, allowing the desired product to be obtained (liquid).

Aufarbeitung

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 2 hours
  3. filtrationThe aluminium compound is filtered off
  4. washrinsed with tetrahydroflran
  5. concentrationThe combined filtrates are concentrated to dryness
  6. customto be obtained (liquid)

Quellen und Nachweise

ORD-Eintrag
ord-9fa619de0f9a40589588bee84f4458b7
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06943184B2

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