Iodine chloride → 2-Amino-5-iodobenzenesulfonamide

HRID 496122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 496122
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[I:12]Cl>C(Cl)(Cl)Cl>[I:12][C:5]1[CH:6]=[CH:7][C:2]([NH2:1])=[C:3]([S:8]([NH2:11])(=[O:9])=[O:10])[CH:4]=1

Komponenten

4

Edukt 2

HCID 24640Iodine chlorideHCID 728942-Aminobenzenesulfonamide

Produkt 1

HCID 223240882-Amino-5-iodobenzenesulfonamideAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

To a cold (0° C.) stirred solution of 2-aminobenzenesulfonamide (17.2 g; 100 mmol) in CHCl3 (200 ml) was added a solution of iodine monochloride (17.1 g; 105 mmol) in CHCl3 (50 ml) over 1 h. The reaction mixture was slowly warmed up to rt. and left with stirring over night. The reaction mixture was filtered and the isolated solid was washed on the filter with CHCl3 (3×20 ml), NaHCO3 (sat. aq., 1×20 ml), H2O (4×50 ml). The isolated solid was air dried to give 27.3 g (92%) of product.

Aufarbeitung

  1. waitand left
  2. filtrationThe reaction mixture was filtered
  3. washthe isolated solid was washed on the
  4. filtrationfilter with CHCl3 (3×20 ml), NaHCO3 (sat. aq., 1×20 ml), H2O (4×50 ml)
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-dcd13d7f0bdc4a148a5865aa46d4f205
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06943159B1

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