Diethyl (ethoxymethylene)malonate → HCID 22322171, Verbindung

HRID 496581

Reaktionsgleichung

Reaktionsgleichung von HRID 496581
[C:1]1([N:7]2[C:11]([NH2:12])=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O[CH:16]=[C:17]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[C:18]([O:20][CH2:21][CH3:22])=[O:19])C>>[CH2:21]([O:20][C:18](=[O:19])[C:17](=[CH:16][NH:12][C:11]1[N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]=[CH:9][CH:10]=1)[C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH3:22]

Komponenten

3

Edukt 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 700061-Phenylpyrazol-5-ylamine

Produkt 1

HCID 22322171HCID 22322171, Verbindung

Versuchsvorschrift

A mixture of 15.9 g. (0.10 mole) of 1-phenyl-5-aminopyrazole and 21.6 g. (0.10 mole) of diethyl ethoxymethylenemalonate was heated at 115-120° in an oil bath for 2 hours. After cooling, the crystalline mass was recrystallized from hot hexane containing 1% of ethanol. Cooling to room temperature and filtering gave 24.8 g. (75%) of off-white crystals, m.p. 96-97° C.

Aufarbeitung

  1. additionA mixture of 15.9 g
  2. temperatureAfter cooling
  3. customthe crystalline mass was recrystallized from hot hexane containing 1% of ethanol
  4. filtrationfiltering
  5. customgave 24.8 g

Quellen und Nachweise

ORD-Eintrag
ord-60679c5493b845128f880a7f14bce9ac
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06946473B2

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