Glycerol → 1-o-t-Butyldimethylsilyl-2-o-methyl-rac-glycerol

HRID 497003Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 497003
OCC(CO)O.C([O:14][CH2:15][CH:16]([CH2:19][O:20][Si:21]([C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:23])[CH3:22])[O:17][CH3:18])C1C=CC=CC=1>[Pd].CO>[Si:21]([O:20][CH2:19][CH:16]([CH2:15][OH:14])[O:17][CH3:18])([C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:23])[CH3:22]

Komponenten

5

Edukt 2

HCID 753GlycerolHCID 223164691-o-Benzyl-3-o-t-butyldimethylsilyl-2-o-methyl-rac-glycerol

Produkt 1

HCID 223164511-o-t-Butyldimethylsilyl-2-o-methyl-rac-glycerolAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of the protected glycerol derivative Compound 41 (5.0 g, 16 mmol) and 10% palladium on activated carbon (wet Degussa type E101 NE/W) (0.43 g) in MeOH (50 mL) was evacuated using an aspirator pump and filled with hydrogen. After 2 hours, TLC analysis showed the reaction to be complete, the mixture was filtered through Celite and the filtrate was evaporated to dryness to give 1-O-t-butyldimethylsilyl-2-O-methyl-rac-glycerol (Compound 42) (99%) as a colourless oil.

Aufarbeitung

  1. customwas evacuated
  2. additionfilled with hydrogen
  3. customthe reaction
  4. filtrationthe mixture was filtered through Celite
  5. customthe filtrate was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-da0205b18e9b49a5b0ed077466269ef5
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949528B1

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