Bromine → 2-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-one

HRID 497300Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 497300
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[OH:8].[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([F:1])[CH:3]=1)=[O:11]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 27373251-(3-Fluoro-4-hydroxyphenyl)ethan-1-one

Produkt 1

HCID 179235302-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-oneAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 1-(3-fluoro-4-hydroxyphenyl)-1-ethanone (2.0 g, 12.98 mmol) in dioxane (3 ml) was added a solution of bromine (2.09 g, 13.1 mmol) in dioxane (12 ml), and the mixture was stirred for 16 hours. The mixture was concentrated in vacuo to give title compound (3.02 g, 99% yield). The compound was used for next reaction without purification.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-25a4e902a54e4b2e9f9e10a3da35d97c
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949536B2

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