N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide → 4-fluoro-N-(piperidin-4-yl)benzamide

HRID 49775

Reaktionsgleichung

Reaktionsgleichung von HRID 49775
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:23])[C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CO>[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15](=[O:23])[C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH2:12][CH2:13]1

Komponenten

4

Edukt 1

HCID 702501N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide

Produkt 1

HCID 47782264-fluoro-N-(piperidin-4-yl)benzamideAusbeute 97,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide (937 mg) and 10% palladium on carbon (50% wet, 0.2 g) in methanol (20 ml) was stirred under hydrogen atmosphere for 7.5 hours at ambient temperature. The catalyst was removed by glass filter and the solvent was removed under reduced pressure. After rinse with diisopropyl ether, N-(piperidin-4-yl)-4-fluorobenzamide (653 mg) was obtained.

Aufarbeitung

  1. customThe catalyst was removed by glass
  2. filtrationfilter
  3. customthe solvent was removed under reduced pressure
  4. washAfter rinse with diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-86d50f487be049008b0004230cdd7116
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06710043B1

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