Water → 5-Bromo-2-chloro-4-(4-methoxyphenoxy)pyrimidine

HRID 49800Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 49800
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[Br:1][C:2]1[C:3]([O:18][C:15]2[CH:16]=[CH:17][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 90154-MethoxyphenolHCID 11430Potassium CarbonateHCID 2899735-Bromo-2,4-dichloropyrimidine

Produkt 1

HCID 729424805-Bromo-2-chloro-4-(4-methoxyphenoxy)pyrimidineAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 5-bromo-2,4-dichloropyrimidine (5.0 g, 22.0 mmol), 4-methoxyphenol (2.72 g, 22.0 mmol) and potassium carbonate (6.07 g, 44.0 mmol) in DMF (20 ml) was stirred for 24 hours. The mixture was added to water (100 ml) and the solid which separated out was collected by filtration, washed with water (50 ml) and dried under high vacuum to give the product (6.6 g, 96%). NMR: 3.8 (s, 3H), 7.0 (d, 2H), 7.2 (d, 2H), 8.8 (s, 11H).

Aufarbeitung

  1. customthe solid which separated out
  2. filtrationwas collected by filtration
  3. washwashed with water (50 ml)
  4. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-3e446067941849988187fc1f41cc13cb
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06710052B2

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