Hydrochloric Acid → 3-Methyl-1-(3-pyridinyl)-1H-pyrazol-5-ylamine dihydrochloride

HRID 498057

Reaktionsgleichung

Reaktionsgleichung von HRID 498057
N/[C:2](=[CH:5]\[CH3:6])/[C:3]#[N:4].[ClH:7].Cl.[NH:9]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[NH2:10].Cl>O>[ClH:7].[ClH:7].[CH3:6][C:5]1[CH:2]=[C:3]([NH2:4])[N:9]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[N:10]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 171324893-Hydrazinylpyridine dihydrochlorideHCID 86589747Aminocrotononitrile

Produkt 1

HCID 574176993-Methyl-1-(3-pyridinyl)-1H-pyrazol-5-ylamine dihydrochlorideAusbeute 96,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of aminocrotononitrile (8.21 g, 100 mmol) and 3-hydrazinopyridine dihydrochloride (20.7 g, 114 mmol) in water (50 mL) was mixed with conc. hydrochloric acid (15 mL), and the mixture was heated under reflux for 30 minutes. The solution was allowed to cool to room temperature, and the reaction solvent was evaporated under reduced pressure, and the resulting crystals were collected by filtration. The crystals obtained were washed with water and air dried to give the title compound (13.6 g, 55% yield).

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. customthe reaction solvent was evaporated under reduced pressure
  4. filtrationthe resulting crystals were collected by filtration
  5. customThe crystals obtained
  6. washwere washed with water and air
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-477c0bb6523b4f85baa2fe527a4edd3e
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949648B2

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