(5-Dimethylamino-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester → Carbamic acid,n-[2-amino-5-(dimethylamino)-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl ester

HRID 498188Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 498188
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:2])[CH3:3]

Komponenten

3

Edukt 1

HCID 69486578(5-Dimethylamino-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 67362752Carbamic acid,n-[2-amino-5-(dimethylamino)-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

The title compound was prepared from (5-dimethylamino-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example C1) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as an amorphous yellow substance (1.34 g).

Aufarbeitung

  1. customObtained as an amorphous yellow substance (1.34 g)

Quellen und Nachweise

ORD-Eintrag
ord-0b099d5df2a04c96997319d58eaac81e
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949542B2

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