(2-Nitro-4-trifluoromethoxy-phenyl)-carbamic acid tert-butyl ester → Carbamic acid,[2-amino-4-(trifluoromethoxy)phenyl]-,1,1-dimethylethyl ester

HRID 498213

Reaktionsgleichung

Reaktionsgleichung von HRID 498213
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:2])[CH3:3]

Komponenten

3

Edukt 1

HCID 69489589(2-Nitro-4-trifluoromethoxy-phenyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 69489489Carbamic acid,[2-amino-4-(trifluoromethoxy)phenyl]-,1,1-dimethylethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

The title compound was prepared from (2-nitro-4-trifluoromethoxy-phenyl)-carbamic acid tert-butyl ester (Example A22) (10.38 g, 32.2 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a light brown solid (8.76 g, 93%).

Quellen und Nachweise

ORD-Eintrag
ord-2fac2924806b4032976ad77bf9f8f930
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949542B2

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