Water → 4-(Morpholin-4-yl)benzoic acid

HRID 49831

Reaktionsgleichung

Reaktionsgleichung von HRID 49831
[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]#N)=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O1CCOCC1.[OH-:21].[K+].[OH2:23]>>[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]([OH:23])=[O:21])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 312751,4-DioxaneHCID 3948084-Morpholinobenzonitrile

Produkt 1

HCID 3452784-(Morpholin-4-yl)benzoic acidAusbeute 99 %

Versuchsvorschrift

A solution of 4-(4-morpholinyl)benzonitrile (930 mg, 5.00 mmol) in 1:1 dioxane:water (20 mL) was treated with potassium hydroxide (1.12 g, 20 mmol). The mixture was heated at reflux for 96 h, concentrated, and the residue was dissolved in water. Upon acidification (pH ˜2-3), a white precipitate resulted which was collected by filtration yielding 1.21 g (99%) of the title compound.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 96 h
  3. concentrationconcentrated
  4. dissolutionthe residue was dissolved in water
  5. customUpon acidification (pH ˜2-3), a white precipitate resulted which
  6. filtrationwas collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-7ad0d7d1880144fa87a13458aa991f81
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06710057B2

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