Water → 4-(Morpholin-4-yl)benzoic acid
Reaktionsgleichung
[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]#N)=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O1CCOCC1.[OH-:21].[K+].[OH2:23]>>[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]([OH:23])=[O:21])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1Komponenten
5
Versuchsvorschrift
A solution of 4-(4-morpholinyl)benzonitrile (930 mg, 5.00 mmol) in 1:1 dioxane:water (20 mL) was treated with potassium hydroxide (1.12 g, 20 mmol). The mixture was heated at reflux for 96 h, concentrated, and the residue was dissolved in water. Upon acidification (pH ˜2-3), a white precipitate resulted which was collected by filtration yielding 1.21 g (99%) of the title compound.
Aufarbeitung
- temperatureThe mixture was heated
- temperatureat reflux for 96 h
- concentrationconcentrated
- dissolutionthe residue was dissolved in water
- customUpon acidification (pH ˜2-3), a white precipitate resulted which
- filtrationwas collected by filtration
Quellen und Nachweise
- ORD-Eintrag
- ord-7ad0d7d1880144fa87a13458aa991f81
- Quelldatensatz
- uspto-grants-2004_03
- Patentnummer
- US06710057B2
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