Hydrazine hydrate (1:1) → 6-(Pyridin-2-yl)pyridazin-3-ol
Reaktionsgleichung
C([O:3][C:4](=O)[CH:5](O)[CH2:6][C:7](=O)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)C.O.[NH2:18][NH2:19]>>[N:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:7]1[CH:6]=[CH:5][C:4](=[O:3])[NH:18][N:19]=1Komponenten
3
Versuchsvorschrift
A solution of 2-hydroxy-4-oxo-4-pyridin-2-ylbutyric acid ethyl ester (2.910 g, 13.000 mmol) in 20 mL of 1-buanol was treated with 0.65 mL (1:1 ratio) of hydrazine hydrate, and the mixture was refluxed overnight. The solvents were evaporated to dryness to give 2.000 g (11.500 mmol) of 6-pyridin-2-yl-2H-pyridazin-3-one as a dark solid, which was used in the next step without further purification.
Aufarbeitung
- temperaturethe mixture was refluxed overnight
- customThe solvents were evaporated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-273dd24ba0ba495788c9412699e28118
- Quelldatensatz
- uspto-grants-2010_08
- Patentnummer
- US07767677B2
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