Hydrochloric Acid → 1-(2-Methoxy-5-propylphenyl)ethanone

HRID 499220

Reaktionsgleichung

Reaktionsgleichung von HRID 499220
[Al+3].[Cl-].[Cl-].[Cl-].[C:5](Cl)([CH3:7])=[O:6].[CH2:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[CH2:10][CH3:11].Cl>ClCCl>[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:9][CH2:10][CH3:11])=[CH:13][C:14]=1[C:5](=[O:6])[CH3:7]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 77024-PropylanisoleHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 684544751-(2-Methoxy-5-propylphenyl)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

A suspension of 10.6 g of AlCl3 in 150 ml of dichloromethane is cooled to −10° C. 5.7 ml of AcCl and 6 g of 4-propylanisole are added. The medium is stirred at −10° C. for 30 min, and then poured into a beaker containing ice mixed with 35% HCl. After separation by settling out, the aqueous phase is extracted 3 times in dichloromethane, and the combined organic phases are washed with water and with a saturated NaCl solution, dried over MgSO4 and then evaporated, to give 7.86 g of a brown oil (quant.).

Aufarbeitung

  1. additionpoured into a beaker
  2. additioncontaining ice
  3. customAfter separation
  4. extractionthe aqueous phase is extracted 3 times in dichloromethane
  5. washthe combined organic phases are washed with water and with a saturated NaCl solution
  6. dry with materialdried over MgSO4
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-ff7b12e1e5114d81b9ff79a24e6944c5
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07767681B2

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