Hydrochloric Acid → 4-Methylpyridine-2-carbaldehyde

HRID 499442

Reaktionsgleichung

Reaktionsgleichung von HRID 499442
[H-].C([Al+]CC(C)C)C(C)C.C1(C)C=CC=CC=1.[C:18]([C:20]1[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][N:21]=1)#N.Cl.[OH2:28]>ClCCl>[CH3:26][C:24]1[CH:23]=[CH:22][N:21]=[C:20]([CH:18]=[O:28])[CH:25]=1

Komponenten

7

Edukt 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 1140TolueneHCID 887392-Cyano-4-methylpyridineHCID 21225700Diisobutylaluminumhydride

Produkt 1

HCID 100118944-Methylpyridine-2-carbaldehydeAusbeute 37 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Diisobutyl aluminium hydride in toluene (1.5 M, 43.5 ml, 65 mmol) was added dropwise to a solution of 2-cyano-4-methylpyridine (7.0 g, 59 mmol) in dichloromethane (180 ml) at −78° C., and the mixture was stirred at the same temperature for 2 hrs. The reaction mixture was combined with concentrated hydrochloric acid (28 ml) and water (112 ml), and the water layer and the organic layer were separated. The organic layer was extracted with 2 N hydrochloric acid. The water layer was combined, neutralized with sodium hydrogen carbonate and extracted with diethyl ether. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (2.7 g, 37%).

Aufarbeitung

  1. customthe water layer and the organic layer were separated
  2. extractionThe organic layer was extracted with 2 N hydrochloric acid
  3. extractionextracted with diethyl ether
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-65705814b0f04cb395f98bac412e3761
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07767665B2

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