Hydrochloric Acid → 2-Fluoro-5-(trifluoromethyl)aniline

HRID 49954

Reaktionsgleichung

Reaktionsgleichung von HRID 49954
[N+:1]([C:4]1[CH:5]=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:7]=[CH:8][C:9]=1[F:10])([O-])=O.Cl.C(=O)(O)[O-].[Na+].C(OCC)C>CO.[Fe]>[F:10][C:9]1[CH:8]=[CH:7][C:6]([C:11]([F:12])([F:13])[F:14])=[CH:5][C:4]=1[NH2:1]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 677784-Fluoro-3-nitrobenzotrifluorideHCID 516892Sodium Bicarbonate

Produkt 1

HCID 1363492-Fluoro-5-(trifluoromethyl)anilineAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Twenty grams of 3-nitro-4-fluorobenzotrifluoride was dissolved in 50 ml of methanol. An iron powder (16 g) was added and concentrated hydrochloric acid was added dropwise with stirring. The reaction mixture was stirred overnight, followed by addition of sodium bicarbonate for neutralization. Then diethyl ether was added, and the insolubles were filtered off with cerite. The ether phase was separated, dried and concentrated under reduced pressure, giving 14 g of the contemplated product (yield 82%).

Aufarbeitung

  1. stirringThe reaction mixture was stirred overnight
  2. filtrationthe insolubles were filtered off with cerite
  3. customThe ether phase was separated
  4. customdried
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-67f0e5b6c7a5411682cf7addfc7c992c
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06710062B1

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