Acetic Anhydride → 3-(2-Pyridyl)propyl acetate

HRID 499571

Reaktionsgleichung

Reaktionsgleichung von HRID 499571
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][OH:10].[C:11](OC(=O)C)(=[O:13])[CH3:12]>N1C=CC=CC=1>[C:11]([O:10][CH2:9][CH2:8][CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)(=[O:13])[CH3:12]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 72922Pyripropanol

Produkt 1

HCID 234486323-(2-Pyridyl)propyl acetateAusbeute 99,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

2-Pyridinepropanol (2.0 g, 14.6 mmol) was dissolved in pyridine (5 ml), and acetic anhydride (3.0 g, 29.2 mmol) was added thereto. The reaction mixture was stirred at room temperature for 2.5 hrs, and subjected to a silica gel (75 g) column chromatography. The fractions eluted with hexane-ethyl acetate (3:1, v/v) were collected and concentrated to give the titled compound (2.6 g, 99%).

Aufarbeitung

  1. washThe fractions eluted with hexane-ethyl acetate (3:1
  2. customv/v) were collected
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-c448b787721b4073b3743c225cff8fc7
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07767665B2

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