Hydrochloric Acid → Sibutramine Hydrochloride

HRID 50046Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 50046
[CH3:1][CH:2]([CH2:4][CH:5]([N:17]([CH3:19])[CH3:18])[C:6]1([C:10]2[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=2)[CH2:9][CH2:8][CH2:7]1)[CH3:3].[ClH:20]>CC(OC)(C)C.C(OCC)C>[CH3:3][CH:2]([CH2:4][CH:5]([N:17]([CH3:18])[CH3:19])[C:6]1([C:10]2[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=2)[CH2:7][CH2:8][CH2:9]1)[CH3:1].[ClH:20]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 5210Sibutramine

Produkt 1

HCID 64764Sibutramine Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 15413tert-Butyl methyl etherLösungsmittel

Versuchsvorschrift

Sibutramine free base (2.25 g) was dissolved in MTBE (20 mL) and that solution was added to 20 mL 1M HCl in diethyl ether. The reaction mixture was stirred for 30 minutes, and the solid was collected by filtration to give 1.73 g after drying. The product was characterized by 1H NMR.

Aufarbeitung

  1. filtrationthe solid was collected by filtration
  2. customto give 1.73 g
  3. customafter drying

Quellen und Nachweise

ORD-Eintrag
ord-94b6c274154349de9ea434c9666d1170
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06710087B2

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