Hydrazine hydrate (1:1) → 2-Methoxyisonicotinohydrazide

HRID 500543Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 500543
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][N:7]=[C:6]([O:10][CH3:11])[CH:5]=1.O.[NH2:14][NH2:15]>C(O)C>[CH3:11][O:10][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][N:7]=1)[C:3]([NH:14][NH2:15])=[O:2]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 14223465Methyl 2-methoxyisonicotinate

Produkt 1

HCID 3225512-MethoxyisonicotinohydrazideAusbeute 80,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

2-Methoxy-isonicotinic acid methyl ester (23.0 g, 137 mmol) and hydrazine hydrate (8.95 g, 178 mmol) were dissolved in ethanol and stirred at 75° C. for 12 hours. The reaction mixture was concentrated and the remaining solid was tritiated in hexanes/ether (80:20), filtered and dried to afford the title compound as a solid (18.4 g, 80%).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. filtrationfiltered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-7a2aeb8ffa114dd899881945ec8d3c9d
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772235B2

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